In 2018, the National Institute for Health and Care Excellence (NICE) published antimicrobial guidance on prescribing for catheterassociated urinary tract infections (CAUTIs). CAUTIs are among the most prevalent healthcare-associated infections, posing significant challenges to patient care and healthcare systems worldwide. Managing CAUTIs requires a multifaceted approach encompassing prevention, early detection, and appropriate intervention strategies. This article discusses the processes involved in improving CAUTI rates and presents a critical review of the current evidence in managing CAUTIs effectively.